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Ankylosing spondylitis(AS)

MedGen UID:
11561
•Concept ID:
C0038013
•
Disease or Syndrome
Synonyms: AS; Disorder of joint of spine; Spondylarthropathies; spondylitis ankylosans
SNOMED CT: Marie-Strumpell spondylitis (9631008); Idiopathic ankylosing spondylitis (9631008); AS - Ankylosing spondylitis (9631008); Ankylosing spondylitis (9631008); Marie Strümpell spondylitis (9631008); Bekhterev's disease (9631008)
 
Monarch Initiative: MONDO:0005306
Orphanet: ORPHA825

Definition

An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnkylosing spondylitis

Professional guidelines

PubMed

ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update.
Ramiro S, Nikiphorou E, Sepriano A, Ortolan A, Webers C, Baraliakos X, Landewé RBM, Van den Bosch FE, Boteva B, Bremander A, Carron P, Ciurea A, van Gaalen FA, Géher P, Gensler L, Hermann J, de Hooge M, Husakova M, Kiltz U, López-Medina C, Machado PM, Marzo-Ortega H, Molto A, Navarro-Compán V, Nissen MJ, Pimentel-Santos FM, Poddubnyy D, Proft F, Rudwaleit M, Telkman M, Zhao SS, Ziade N, van der Heijde D
Ann Rheum Dis 2023 Jan;82(1):19-34. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223296. PMID: 36270658
Treatment of axial spondyloarthritis: an update.
Danve A, Deodhar A
Nat Rev Rheumatol 2022 Apr;18(4):205-216. Epub 2022 Mar 10 doi: 10.1038/s41584-022-00761-z. PMID: 35273385
Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.
Rogler G, Singh A, Kavanaugh A, Rubin DT
Gastroenterology 2021 Oct;161(4):1118-1132. Epub 2021 Aug 3 doi: 10.1053/j.gastro.2021.07.042. PMID: 34358489Free PMC Article

Recent clinical studies

Etiology

Ankylosing spondylitis and psychiatric disorders in European population: a Mendelian randomization study.
Zuo H, Li MM
Front Immunol 2023;14:1277959. Epub 2023 Oct 26 doi: 10.3389/fimmu.2023.1277959. PMID: 37954601Free PMC Article
Recent advances in ankylosing spondylitis: understanding the disease and management.
Garcia-Montoya L, Gul H, Emery P
F1000Res 2018;7 Epub 2018 Sep 21 doi: 10.12688/f1000research.14956.1. PMID: 30345001Free PMC Article
Epidemiology of axial spondyloarthritis: an update.
Wang R, Ward MM
Curr Opin Rheumatol 2018 Mar;30(2):137-143. doi: 10.1097/BOR.0000000000000475. PMID: 29227352Free PMC Article
Genetics and the Causes of Ankylosing Spondylitis.
Hanson A, Brown MA
Rheum Dis Clin North Am 2017 Aug;43(3):401-414. doi: 10.1016/j.rdc.2017.04.006. PMID: 28711142Free PMC Article
Physiotherapy for Ankylosing Spondylitis: Systematic Review and a Proposed Rehabilitation Protocol.
Sharan D, Rajkumar JS
Curr Rheumatol Rev 2017;13(2):121-125. doi: 10.2174/1573397112666161025112750. PMID: 27784233

Diagnosis

Ankylosing spondylitis and psychiatric disorders in European population: a Mendelian randomization study.
Zuo H, Li MM
Front Immunol 2023;14:1277959. Epub 2023 Oct 26 doi: 10.3389/fimmu.2023.1277959. PMID: 37954601Free PMC Article
Editorial: Advances in Pathogenesis, Etiology, and Therapies for Ankylosing Spondylitis.
Chen CW, Wei JC, Gu J, Yu D
Front Immunol 2021;12:822582. Epub 2021 Dec 23 doi: 10.3389/fimmu.2021.822582. PMID: 35003143Free PMC Article
Editorial: Ankylosing Spondylitis and Related Immune-Mediated Disorders.
Fiorillo MT, Haroon N, Ciccia F, Breban M
Front Immunol 2019;10:1232. Epub 2019 Jun 4 doi: 10.3389/fimmu.2019.01232. PMID: 31214188Free PMC Article
Epidemiology of axial spondyloarthritis: an update.
Wang R, Ward MM
Curr Opin Rheumatol 2018 Mar;30(2):137-143. doi: 10.1097/BOR.0000000000000475. PMID: 29227352Free PMC Article
Update on ankylosing spondylitis: current concepts in pathogenesis.
Smith JA
Curr Allergy Asthma Rep 2015 Jan;15(1):489. doi: 10.1007/s11882-014-0489-6. PMID: 25447326

Therapy

Exploring causal correlations between inflammatory cytokines and ankylosing spondylitis: a bidirectional mendelian-randomization study.
Fang P, Liu X, Qiu Y, Wang Y, Wang D, Zhao J, Ding H, Bao N
Front Immunol 2023;14:1285106. Epub 2023 Nov 20 doi: 10.3389/fimmu.2023.1285106. PMID: 38054001Free PMC Article
Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial.
Zeng L, Yang T, Yang K, Yu G, Li J, Xiang W, Chen H
Front Immunol 2022;13:891822. Epub 2022 Jul 22 doi: 10.3389/fimmu.2022.891822. PMID: 35935936Free PMC Article
Paradoxical gastrointestinal effects of interleukin-17 blockers.
Fauny M, Moulin D, D'Amico F, Netter P, Petitpain N, Arnone D, Jouzeau JY, Loeuille D, Peyrin-Biroulet L
Ann Rheum Dis 2020 Sep;79(9):1132-1138. Epub 2020 Jul 21 doi: 10.1136/annrheumdis-2020-217927. PMID: 32719044
2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis.
Ward MM, Deodhar A, Gensler LS, Dubreuil M, Yu D, Khan MA, Haroon N, Borenstein D, Wang R, Biehl A, Fang MA, Louie G, Majithia V, Ng B, Bigham R, Pianin M, Shah AA, Sullivan N, Turgunbaev M, Oristaglio J, Turner A, Maksymowych WP, Caplan L
Arthritis Care Res (Hoboken) 2019 Oct;71(10):1285-1299. Epub 2019 Aug 21 doi: 10.1002/acr.24025. PMID: 31436026Free PMC Article
Physiotherapy interventions for ankylosing spondylitis.
Dagfinrud H, Kvien TK, Hagen KB
Cochrane Database Syst Rev 2008 Jan 23;2008(1):CD002822. doi: 10.1002/14651858.CD002822.pub3. PMID: 18254008Free PMC Article

Prognosis

HLA-B27, axial spondyloarthritis and survival.
Li Z, Khan MK, van der Linden SM, Winkens B, Villiger PM, Baumberger H, van Zandwijk H, Khan MA, Brown MA
Ann Rheum Dis 2023 Dec;82(12):1558-1567. Epub 2023 Sep 7 doi: 10.1136/ard-2023-224434. PMID: 37679034
Vasculitis and inflammatory arthritis.
Watts RA, Scott DG
Best Pract Res Clin Rheumatol 2016 Oct;30(5):916-931. Epub 2016 Nov 9 doi: 10.1016/j.berh.2016.10.008. PMID: 27964796
The classification and diagnostic criteria of ankylosing spondylitis.
Raychaudhuri SP, Deodhar A
J Autoimmun 2014 Feb-Mar;48-49:128-33. Epub 2014 Feb 16 doi: 10.1016/j.jaut.2014.01.015. PMID: 24534717
Epidemiology of spondyloarthritis: a review.
Bakland G, Nossent HC
Curr Rheumatol Rep 2013 Sep;15(9):351. doi: 10.1007/s11926-013-0351-1. PMID: 23888360
Seronegative spondyloarthritis.
Zochling J, Smith EU
Best Pract Res Clin Rheumatol 2010 Dec;24(6):747-56. doi: 10.1016/j.berh.2011.02.002. PMID: 21665123

Clinical prediction guides

Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.
Rogler G, Singh A, Kavanaugh A, Rubin DT
Gastroenterology 2021 Oct;161(4):1118-1132. Epub 2021 Aug 3 doi: 10.1053/j.gastro.2021.07.042. PMID: 34358489Free PMC Article
Modified stoke ankylosing spondylitis spinal score as an outcome measure to assess the impact of treatment on structural progression in ankylosing spondylitis.
van der Heijde D, Braun J, Deodhar A, Baraliakos X, Landewé R, Richards HB, Porter B, Readie A
Rheumatology (Oxford) 2019 Mar 1;58(3):388-400. doi: 10.1093/rheumatology/key128. PMID: 29860356Free PMC Article
Imaging of axial spondyloarthritis. New aspects and differential diagnoses.
Braun J, Baraliakos X, Buehring B, Kiltz U, Fruth M
Clin Exp Rheumatol 2018 Sep-Oct;36 Suppl 114(5):35-42. Epub 2018 Oct 1 PMID: 30296971
One year in review 2017: spondyloarthritis.
Terenzi R, Monti S, Tesei G, Carli L
Clin Exp Rheumatol 2018 Jan-Feb;36(1):1-14. Epub 2018 Feb 5 PMID: 29461959
Uveitis in Spondyloarthritis: An Overview.
Cantini F, Nannini C, Cassarà E, Kaloudi O, Niccoli L
J Rheumatol Suppl 2015 Nov;93:27-9. doi: 10.3899/jrheum.150630. PMID: 26523051

Recent systematic reviews

Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.
Webers C, Ortolan A, Sepriano A, Falzon L, Baraliakos X, Landewé RBM, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):130-141. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223298. PMID: 36270657
Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial.
Zeng L, Yang T, Yang K, Yu G, Li J, Xiang W, Chen H
Front Immunol 2022;13:891822. Epub 2022 Jul 22 doi: 10.3389/fimmu.2022.891822. PMID: 35935936Free PMC Article
Ankylosing spondylitis risk factors: a systematic literature review.
Hwang MC, Ridley L, Reveille JD
Clin Rheumatol 2021 Aug;40(8):3079-3093. Epub 2021 Mar 22 doi: 10.1007/s10067-021-05679-7. PMID: 33754220Free PMC Article
Exercise for ankylosing spondylitis: An evidence-based consensus statement.
Millner JR, Barron JS, Beinke KM, Butterworth RH, Chasle BE, Dutton LJ, Lewington MA, Lim EG, Morley TB, O'Reilly JE, Pickering KA, Winzenberg T, Zochling J
Semin Arthritis Rheum 2016 Feb;45(4):411-27. Epub 2015 Aug 18 doi: 10.1016/j.semarthrit.2015.08.003. PMID: 26493464
Global prevalence of ankylosing spondylitis.
Dean LE, Jones GT, MacDonald AG, Downham C, Sturrock RD, Macfarlane GJ
Rheumatology (Oxford) 2014 Apr;53(4):650-7. Epub 2013 Dec 9 doi: 10.1093/rheumatology/ket387. PMID: 24324212

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